Adherence to Therapy for Inflammatory Bowel Disease in Children

Authors

  • Irina V. Sichinava Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University nave I.M. Sechenov of Russian Federation Ministry of Health (Sechenov University). Department of Children’s Diseases, Сclinical Institute of Children’s Health named after N.F. Filatov. Sechenov Center for Motherhood and Childhood
  • Marika I. Ivardava Pediatrics and Child Health Research Institute of Petrovsky National Research Center of Surgery

DOI:

https://doi.org/10.61699/cjmps-v3-i1-2-p30-44

Keywords:

inflammatory bowel diseases, adherence to treatment, effectiveness of therapy, children, educational programs

Abstract

An analysis of the literature data was carried out to determine adherence to therapy and its significance in inflammatory bowel diseases (IBD). Such significant reasons for low adherence to treatment in children with IBD as psychological and emotional factors, lack of information about the disease, and complex therapy regimens are described. The role of parents and medical professionals to improve treatment adherence is outlined. The consequences of non-compliance with therapy for IBD in children are highlighted. The role of versatile educational programs in the effectiveness of IBD treatment in children is emphasized In conclusion, it was noted that adherence to therapy is a key factor in the successful treatment of IBD in children. The study of this topic is of great importance for practical medicine and requires further study, including the introduction of innovations.

References

Khlynova O.V., Stepina E.A. Khlynova O. V., Stepina E. A. Disturbance of intestinal permeability and its role in the development of cardiovascular complications in persons with inflammatory bowel diseases. Experimental and Clinical Gastroenterology. 2022;207(11): 36-45. (In Russ.) DOI: 10.31146/1682-8658-ecg-207-11-36-45

Tang W. H., Wang Z., Levison B. S., et al.Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. The New England Journal of Medicine. 2013;368(17):1575-1584. https://doi.org/10.1056/NEJMoa1109400

Liu Y., Dai M. Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis. Mediators Inflamm. 2020; 2020:4634172. https://doi.org/10.1155/2020/4634172.

Gordeeva I.G. Allergy to cow’s milk proteins and lactase deficiency in children with inflammatory bowel diseases: Abstract of the dissertation of the Candidate of Medical Sciences. — Moscow, 2023. — 23 p.(In Russ.)

Gordeeva I.G., Makarova S.G., Chernicov V.V., Surkov A.N. Comparative analysis of the number of eosinophils and mast cells in the colon biopsies of children with IBD. Allergy. 2021. V. 76. № S110. С. 347. (In Russ.)

Gordeeva I.G., Makarova S.G., Fisenko A.P., Yasakov D.S. Eosinophils and mast cells of the intestinal mucosa in children with inflammatory bowel diseases and comorbid food allergies. Russian Pediatric Journal. 2022. 25(4): 253-254. doi:10.46563/1560-9561- 2022-25-4-242 292

Makarova S.G., Gordeeva I.G., Surkov A.N. Inflammatory bowel diseases and food allergies: pathogenetic and clinical parallels. Pediatrics. The G.N. Speransky Journal. 2021; 100 (1): 112-119. (In Russ.) (In Russ.) doi: 10.24110/0031-403X-2021-100-1-112-119.

Kamalova A.A., Safina E.R. Nutritional status of children with inflammatory bowel diseases. Practical medicine. 2020. Volume 18, No. 4, pp. 63-68) (In Russ.) DOI: 10.32000/2072-1757-2020-4-63-68

Andreev K.A., Gorbenko A.V., Skirdenko Yu.P., Nikolaev N.A., Livzan M.A., Bikbavova G.R., Fedorin M.M. Adherence to treatment of patients with inflammatory bowel diseases. Bulletin of Siberian medicine. 2021;20(3):120-128. (In Russ.) https://doi.org/10.20538/1682-0363-2021-3-120-128

Uspensky Yu.P. , Fomin Yu.A., Kizimov O.A., Kolgin N.Y.. The state of the psycho -emotional sphere in patients with inflammatory bowel diseases. (In Russ.) DOI: https://dx.doi.org/10.18565/pharmateca.2022.2.30-37

Van Assche G., Peyrin-Biroulet L., Sturm A., et al. Burden of disease and patient-reported outcomes in patients with moderate to severe ulcerative colitis in the last 12 months. Multicenter European cohort study. Dig Liver Dis. 2016;48(6):592- 600. Doi: 10.1016/j.dld.2016.01.011.

Van de star T., Banan A. Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review. Gastroenterol Hepatol Open Access. 2015;2(2):00038. Doi: 10.15406/ghoa.2015.02.00038.

Gibson P., Kruis W., Greinwald R., Mueller R. A combined delayed and extended release formulation of mesalamine demonstrates better clinical outcome in distal, active ulcerative colitis than a solely delayed release formulation. Gut 2009;58(Suppl. II): A-325(P1092).

Vasilenko A.G., Vasilenko Z.G., Nedochukova E.S., Smagi na N.V., Popp V.Ya., Romza L.B., Efimov A.I., Levin M.Z., Efimov I.A. Analysis of the causes of low adherence to treatment in patients with inflammatory bowel diseases. Bulletin of the Chelyabinsk Regional Hospital. 2014; 3: 31–33. (In Russ.)

Ardatskaya M.D., Topchy T.B., Butorova L.I., Tuaeva E.M., Sayutina E.V. Antibiotic-associated intestinal lesions in the practice of a clinician: a manual for doctors / M.D. Ardatskaya, T.B. Topchy, L.I. Butorova, E.M. Tuaeva, E.V. Sayutina. — M.: 2020. 52с.(In Russ.)

Sitkin S.I. Possibilities of improving the effectiveness of therapy and compliance in patients with inflammatory bowel diseases using innovative oral mesalazine preparations. Gastroenterology. 2011. No. 1. pp. 2-3.(In Russ.)

Kruis W., Jonaitis L., Pokrotnieks J., Acute G., Mikhailova T., Horynski M., et al. Once daily 3 g mesalamine is the optimal dose for maintaining clinical remission in ulcerative colitis: a double-blind, double-dummy, randomized, controlled doseranging study. Gastroenterology 2008; 134 (4, Suppl. 1):A-489(T1124)

Zakko S., Gordon G.L., Murthy U.K., Sedghi S., Pruitt R.W., Merchant K., et al. Once-daily mesalamine granules effectively maintain remission from ulcerative colitis: data from 2 phase 3 trials. Gastroenterology 2009;136(Suppl.1):T1202.

Knyazev O.V., Babayan A.F., Kagramanova A.V., Parfenov A.I. Adherence to therapy of inflammatory bowel diseases. The Medical Alphabet. 2019;1(6):13-19. https://doi.org/10.33667/2078-5631-2019-1-6(381)-13-18 (In Russ.)

Kaztaeva A.Sh., Loseva I.V. Compliance to pharmacotherapy in pediatrics: a review of international research // Universum: medicine and pharmacology : electron. scientific journal. 2025. 4(121). URL: https://7universum.com/ru/med/archive/item/19710.(In Russ.)

Ogarev V. V., Sirota N. A., Knyazev O. V., Polyakova V. V., Kanatbek kyzy A., Babayan A. F., Akhmerova P. S., Bodunova N. A. Perception of the disease by patients with inflammatory bowel diseases. Online scientific journal Personality in a changing world: health, adaptation, development 2023.Volume 11. No. 2 (41). pp. 165-173. (In Russ.)

Prevalence and predictors of medication non-adherence in children with inflammatory bowel disease in China: A cross-sectional study ORIGINAL RESEARCH article. Front. Pharmacol., 01 December 2022. Sec. Obstetric and Pediatric Pharmacology. Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1062728

Published

2025-08-09

How to Cite

Sichinava, I. V., & Ivardava, M. I. (2025). Adherence to Therapy for Inflammatory Bowel Disease in Children. The Caucasus Journal of Medical and Psychological Sciences, 3(1-2), 30–44. https://doi.org/10.61699/cjmps-v3-i1-2-p30-44

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Section

Articles